Département de pharmacologie

Mohit KAPOOR, Ph.D.

Accredited member, Department of Pharmacology, Faculty of Medicine

Assistant Research Professor, Department of Medicine, University of Montreal

Canadian Arthritis Network Investigator

Canadian Scleroderma Research Group Investigator

Osteoarthritis Research Unit

Notre-Dame Hospital

University of Montreal Hospital Research Centre (CRCHUM)

1560 Sherbrooke Street East

Montreal, Quebec H2L 4M1

Tel. : 514 890-8000 ext. 25544, Fax : 514 412-7582

Keywords

Arthritis, osteoarthritis, rheumatoid arthritis, inflammation, wound/tissue repair, fibrosis, scleroderma, cartilage growth and development, knockout mice, skin, cytokines, PPARgamma, prostaglandins, growth factors, cell/tissue culture, molecular biology.

Research Interests

My research employs multiple approaches including molecular, genetic and pharmacological tools to identify novel therapeutic targets and signalling pathways involved in cartilage growth and development and in the pathophysiology of osteoarthritis (OA) using genetically mice, animal models of OA and human OA specimens.

My other research interests include identification of mediators and signalling pathways involved in pro-inflammatory and pro-fibrotic responses associated with Scleroderma disease using animal models of fibrosis and human diseased and normal specimens.

Laboratory Research Activities

Understanding the biology of cartilage/bone growth and development.
Understanding the pathophysiology of osteoarthritis
Understanding the pathophysiology of scleroderma disease
Generation of genetically modified mice to understand the pathophysiology of

Osteoarthritis or Scleroderma disease

Contribution of autophagy/stemness in osteoarthritis and scleroderma disease.

Techniques used

Molecular and cellular biology
Biochemistry
Immunology
Pharmacology
Animal models of osteoarthritis and scleroderma disease

Present members

Dr. Yue Zhang: Postdoctoral Fellow
Dr. Parisa Ghassemi: MSc candidate
Faezeh Vasheghani: PhD Candidate
Gemma Perez: Research Assistant
Meryem Blati: Research Assistant

Publications

Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, St-Arnaud R, Taniguchi, N, Lotz M, Pelletier J-P, Martel-Pelletier J, Beier F and Kapoor M. Cartilage-specific deletion of PPARγ results in abnormal endochondral ossification and cartilage growth and development. Arthritis and Rheumatism (2011, Epub Ahead of print).
Kapoor M, Martel-Pelletier J, Lajeunesse D and Fahmi H and. Role of proinflammatory cytokines in the pathophysiology of Osteoarthritis. Nature Reviews Rheumatology, 2011, 7(1):33-42.
McCann MR, Monemdjou R, Ghassemi-Kakroodi, P, Fahmi H, Perez G, Liu S, Shi-wen X, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A and Kapoor M. mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. Arthritis Research and Therapy, 2011 25;13(1):R6.

Publications indexed on pubmed

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=Mohit+kapoor&log$=activity