Johanne MARTEL-PELLETIER, Ph.D.

Accredited member, Department of Pharmacology, Faculty of Medicine

Professor, Department of Medicine

Head, Chair in Osteoarthritis, University of Montreal

Director, Osteoarthritis Research Unit

University of Montreal Hospital Centre Research Centre (CRCHUM), Notre-Dame Hospital

Osteoarthritis Research Unit

Notre-Dame Hospital

University of Montreal Hospital Research Centre (CRCHUM)

1560 Sherbrooke Street East

Montreal, Quebec H2L 4M1

Tel. : 514.890.8000 ext. 27281

Fax : 514. 412-7582

Formation

BSc, Molecular Biology (1973), UQAM
Master's Degree in Physiology (1975), PhD in Physiology (1979), Department of Medicine, University of Montreal
Postdoctoral studies, Department of Biophysics, University of Montreal, Montreal, Quebec (1978-1979) and Department of Medicine (Rheumatology), University of Miami, Miami, Florida (1979-1981)

Mechanisms underlying the pathophysiology of osteoarthritis
Study of new anti-arthritic molecules, ex vivo in humans and in vivo in animal models, and of anti- and pro-catabolic molecules
Study of molecular mechanisms of metalloproteases and of pro- and anti-inflammatory cytokines
Study of the pathophysiology of subchondral bone in osteoarthritis
Mouse models of OA, Knock-out, overexpression in tissue conditional manner

Amiable, N., Martel-Pelletier, J., Lussier, B., Kwan Tat, S., Pelletier, J-P., Boileau, C.: Proteinase-activated receptor-2 gene disruption limits the effect of osteoarthritis on cartilage in mice: a novel target in joint degradation. J. Rheumatol. 38(5):911-920, 2011.
Boileau, C., Martel-Pelletier, J., Caron, J., Paré, F., Troncy, É., Moreau, M., Pelletier, J-P.: Oral treatment with brachystemma calycinum D. don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease activated receptor-2 (PAR-2). Ann. Rheum. Dis. 69:1179-84, 2010.
Kwan Tat, S., Amiable, N., Pelletier, J-P., Boileau, C., Lajeunesse, D., Duval, N., Martel-Pelletier, J.: Modulation of OPG, RANK, RANKL by human chondrocytes and their implication during osteoarthritis. Rheumatology 458:1482-1490, 2009.

Kwan Tat, S., Pelletier, J-P., Amiable, N., Boileau C., Lavigne, M., Martel-Pelletier, J.: Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes. Arthritis Res. Ther. 11:R119, 2009.
Tardif, G., Hum, D., Pelletier, J-P., Duval, N., Martel-Pelletier. J.: Regulation of the IGFBP-5 and MMP-13 genes by the micoRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskeletal Disorders 10:148-158, 2009.